Kwon, S. W., Moon, J. K., Song, S. C., Cha, J. Y., Kim, Y. W., Choi, Y. J., Lee, J. S.*. "Time-series X-ray image prediction of dental skeleton treatment progress via neural networks", Computers in Biology and Medicine (2025).
This study addresses the challenges in accurately predicting skeletal changes during orthodontic treatment in growing patients by utilizing advanced generative neural networks, specifically denoising diffusion probabilistic models (DDPM), latent diffusion models (LDM), and ControlNet. Traditional approaches, such as support vector regression and multilayer perceptrons, rely heavily on multiple sequential radiographs, increasing radiation exposure and landmark identification errors without providing visually interpretable predictions. In contrast, the diffusion-based methods explored in this research demonstrate superior predictive accuracy and clinical practicality with minimal input images, notably achieving comparable performance with a single-input LDM and ControlNet. These methods significantly reduce clinical requirements, patient visits, and radiation exposure, offering personalized, visually interpretable orthodontic treatment plans based on patient-specific attributes, thereby marking a substantial advancement in orthodontic predictive modeling.